Tyewhoppety () is an unincorporated community located in Todd County, Kentucky, United States. The community is located on Kentucky Route 181 14.5 miles (23.3 km) north of Elkton.
The etymology of the community's name is unknown; it may refer to a slang term for an "unkempt, ill-appearing person" or a Shawnee word meaning "place of no return". Tyewhoppety was declared the "most difficult to pronounce" place name in the state of Kentucky by Reader's Digest.
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